{{:small_butte_lab_logo.png|Butte Lab logo}}








====== Introduction to the Butte Lab ======

The long-term research goal of the **Butte Lab** is to develop bioinformatics methods in **integrative biology**, or reasoning over the many available genome-scale measurement and experimental modalities, and apply these methods to study complex disorders in genomic medicine, especially obesity and type 2 diabetes mellitus.

The Butte Lab has three main directions in exploring integrative biology. First, we have developed bioinformatics methods to integrate genomic, genetic, phenotypic, and RNAi data from multiple sources and phenotypes and reason over these data.  An example of this was our [[http://bmir.stanford.edu/publications/view.php/prediction_of_preadipocyte_differentiation_by_gene_expression_reveals_role_of_insulin_receptor_substrates_and_necdin|work]] in adipogenesis published in //Nature Cell Biology// (2005) and our work in obesity [[http://bmir.stanford.edu/publications/view.php/evaluation_and_integration_of_49_genome_wide_experiments_and_the_prediction_of_previously_unknown_obesity_related_genes|published]] in //Bioinformatics// (2007).  Second, we have developed tools to automatically index and find genomic and proteomic data sets based on the phenotypic and contextual details of each experiment.  We used these tools to create a comprehensive phenome-genome network [[http://bmir.stanford.edu/publications/view.php/creation_and_implications_of_a_phenome_genome_network|published]] in //Nature Biotechnology// (2006), using tools [[http://bmir.stanford.edu/publications/view.php/3726|published]] in //Nature Methods// (2007).  Third, we are building novel classification scheme for diseases across the entire field of medicine, using clinical data, as we [[http://bmir.stanford.edu/publications/view.php/the_ultimate_model_organism|described]] in //Science// (2008), and using gene-expression data, as described in the [[http://www.nytimes.com/2008/05/06/health/research/06dise.html|New York Times]] and [[http://www.iht.com/articles/2008/05/06/arts/snclassify.php|International Herald Tribune]].

The Butte Lab is in the [[http://bmir.stanford.edu|Stanford Center for Biomedical Informatics Research]] (formally Stanford Medical Informatics or SMI), in the [[http://medicine.stanford.edu/|Department of Medicine]] and [[http://pediatrics.stanford.edu/|Department of Pediatrics]], in the [[http://med.stanford.edu|Stanford University School of Medicine]], and is a core faculty laboratory in the [[http://bmi.stanford.edu|Biomedical Informatics Training Program]] at [[http://stanford.edu|Stanford University]].

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