Lab Publications

Reference Publication
I. Balboni, S. M. Chan, M. Kattah, J. Tenenbaum, A. J. Butte, P. J. Utz. Multiplexed Protein Array Platforms for Analysis of Autoimmune Diseases. Annual Review of Immunology, 24:391–418. 2006 Publication
A. J. Butte, I. S. Kohane. Creation and implications of a phenome-genome network. Nature Biotechnology,24(1):55 - 62. 2006 Publication
C. J. Wolfe, I. S. Kohane, A. J. Butte. Systematic survey reveals general applicability of “guilt-by-association” within gene coexpression networks.. BMC Bioinformatics,6(227)2005 Publication
J. K. Ichikawa, S. B. English, M. C. Wolfgang, R. Jackson, A. J. Butte, S. Lory. Genome-wide analysis of host responses to the Pseudomonas aeruginosa yields synergistic effects. Cellular Microbiology,7(11):1635–1646. 2005 Publication
J. Pollard, A. J. Butte, S. Hoberman, M. Joshi, J. Levy, J. Pappo. A Computational Model to Define the Molecular Causes of Type 2 Diabetes Mellitus. DIABETES TECHNOLOGY & THERAPEUTICS,7(2):323-336. 2005 Publication
Y. Tseng, A. J. Butte, E. Kokkotou, V. K. Yechoor, C. M. Taniguchi, K. M. Kriauciunas, A. M. Cypess, M. Niinobe, K. Yoshikawa, M. E. Patti, C. Kahn. Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin. NATURE CELL BIOLOGY,7(6):601-614. 2005 Publication
A. T. Kho, Q. Zhao, Z. Cai, A. J. Butte, J. Y. Kim, S. L. Pomeroy, D. H. Rowitch, I. S. Kohane. Conserved mechanisms across development and tumorigenesis revealed by a mouse development perspective of human cancers. GENES & DEVELOPMENT,18:629-640. 2004 Publication
A. B. Csoka, S. B. English, C. P. Simkevich, D. G. Ginzinger, A. J. Butte, G. P. Schatten, F. G. Rothman, J. M. Sedivy. Genome-scale expression profiling of Hutchinson–Gilford progeria syndrome reveals widespread transcriptional misregulation leading to mesodermal/mesenchymal defects and accelerated atherosclerosis. Aging Cell,:1-9. 2004 Publication
D. J. Allocco, I. S. Kohane, A. J. Butte. Quantifying the relationship between co-expression, co-regulation and gene function. BMC Bioinformatics,5(18)2004 Publication
D. L. Weiner, A. J. Butte, P. L. Hibberd, G. R. Fleisher. Computerized Recruiting for Clinical Trials in Real Time. ANNALS OF EMERGENCY MEDICINE,41(2):242-246. 2003 Publication
M. E. Patti, A. J. Butte, S. Crunkhorn, K. Cusi, R. Berria, S. Kashyap, Y. Miyazaki, I. S. Kohane, M. Costello, R. Saccone, E. J. Landaker, A. B. Goldfine, E. Mun, R. DeFronzo, J. Finlayson, C. Kahn, L. J. Mandarino. Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. Proceedings of the National Academy of Sciences,(PNAS), 100(14):8466–8471. 2003 Publication
A. Nimgaonkar, D. Sanoudou, A. J. Butte, J. N. Haslett, H. M. Kunkel, A. H. Beggs, I. S. Kohane. Reproducibility of gene expression across generations of Affymetrix microarrays. BMC Bioinformatics,4:1-12. 2003 Publication
K. Y. Lee, I. S. Kohane, A. J. Butte. PGAGENE: integrating quantitative gene-specific results from the NHLBI Programs for Genomic Applications. BIOINFORMATICS APPLICATIONS NOTE,19(6):778-779. 2003 Publication
A. J. Butte. Automated Assessments in Health Care Quality. Improving the Quality of Primary Care,32:50-62. 2002 Publication
P. J. Park, A. J. Butte, I. S. Kohane. Comparing expression profiles of genes with similar promoter regions. BIOINFORMATICS,18(12):1576–1584. 2002 Publication
W. P. Kuo, T. Jenssen, A. J. Butte, L. Ohno-Machado, I. S. Kohane. Analysis of matched mRNA measurements from two different microarray technologies. BIOINFORMATICS,0(0):1-9. 2002 Publication
A. J. Butte, L. Bao, B. Y. Reis, T. W. Watkins, I. S. Kohane. Comparing the Similarity of Time-Series Gene Expression Using Signal Processing Metrics. Journal of Biomedical Informatics,34:396-405. 2002 Publication
A. J. Butte. THE USE AND ANALYSIS OF MICROARRAY DATA. Nature Reviews: Drug Discovery,1:951-960. 2002 Publication
A. Riva, K. D. Mandl, D. Oh, D. J. Nigrin, A. J. Butte, P. Szolovits, I. S. Kohane. The Personal Internetworked Notary and Guardian. International Journal of Medical Informatics,60:27-40. 2001 Publication
B. Y. Reis, A. J. Butte, I. S. Kohane. Extracting Knowledge from Dynamics in Gene Expression. Journal of Biomedical Informatics,34:15-27. 2001 Publication
A. J. Butte. Challenges in bioinformatics: infrastructure, models and analytics. TRENDS in Biotechnology,19(5):159-160. 2001 Publication
A. J. Butte, J. YE, G. NIEDERFELLNER, K. RETT, H. U. HÄRING, M. F. WHITE, I. S. Kohane. DETERMINING SIGNIFICANT FOLD DIFFERENCES IN GENE EXPRESSION ANALYSIS. 2001. Publication
A. J. Butte, J. S. Shaw, H. Bernstein. Strict interpretation of vaccination guidelines with computerized algorithms and improper timing of administered doses. THE PEDIATRIC INFECTIOUS DISEASE JOURNAL,20(6):561-565. 2001 Publication
A. J. Butte, V. J. Dzau, S. B. Glueck. Further defining housekeeping, or “maintenance,” genes Focus on “A compendium of gene expression in normal human tissues”. Physiol Genomics,7:95-96. 2001 Publication
S. A. Huang, H. M. Tu, J. W. Harney, M. Venihaki, A. J. Butte, H. P. Kozakewich, S. J. Fishman, P. Re. Larson. SEVERE HYPOTHYROIDISM CAUSED BY TYPE 3 IODOTHYRONINE DEIODINASE IN INFANTILE HEMANGIOMAS. The New England Journal of Medicine,343(3):185-189. 2000 Publication
A. J. Butte, I. S. Kohane. MUTUAL INFORMATION RELEVANCE NETWORKS: FUNCTIONAL GENOMIC CLUSTERING USING PAIRWISE ENTROPY MEASUREMENTS. 2000. Publication
A. J. Butte, P. Tamayo, D. Slonim, T. R. Golub, I. S. Kohane. Discovering functional relationships between RNA expression and chemotherapeutic susceptibility using relevance networks. 2000. Publication
A. J. Butte, D. A. Weinstein, I. S. Kohane. Enrolling Patients Into Clinical Trials Faster Using RealTime Recuiting. 2000. Publication
A. J. Butte, I. S. Kohane. Unsupervised Knowledge Discovery in Medical Databases Using Relevance Networks. 1999. Publication
M. J. Quon, M. Guerre-Millo, M. Zarnowski, A. J. Butte, M. Em, S. W. Cushman, S. I. Taylor. Tyrosine kinase-deficient mutant human insulin receptors (Met1153–>Ile) overexpressed in transfected rat adipose cells fail to mediate translocation of epitope-tagged GLUT4. Proc Natl Acad Sci U S A.,91(12):5587-5591. 1994 Publication
M. J. Quon, A. J. Butte, M. Zarnowski, G. Sesti, S. W. Cushman, S. I. Taylor. Insulin Receptor Substrate 1 Mediates the Stimulatory Effect of Insulin on GLUT4 Translocation in Transfected Rat Adipose Cells. THE JOURNAL OF BIOLOGICAL CHEMISTRY,269(45):27920-27924. 1994 Publication
P. B. DePetrillo, A. J. Butte. Derivation of Scale-Independent Parameter Which Characterizes Genetic Sequence Comparisons. Computers and Biomedical Research: An International Journal,26(6):517-540. 1993 Publication
B. Rotman, A. J. Butte. A Computer-Simulated “Wet Laboratory”. Biochemical Education,20(3):139-141. 1992 Publication
 
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